Appletree CI Group

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Appletree CI Group is an expert niche CRO/CSO and global regulatory affairs service provider with track records in ophthalmology and medical device investigations.

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Type Public
Industry Pharmaceuticals
Founded 1992
Headquarters Rudolf-Diesel-Strasse 3

8404 Winterthur Switzerland

Number of employees 11-50 employees


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In 1992 Clinical Investigations was founded by Dr. Gerhard Krejci. Clinical Investigations has constantly grown since. In 2002, Dr. Georg Mathis together with two partners founded Appletree AG, a niche CRO focusing on ophthalmology and medical device investigations, in a later stage also on regulatory affairs world-wide. In April 2013, both companies – having about the same size – merged into Appletree CI Group with headquarters in Winterthur (Switzerland). In January 2014, Appletree CI Group acquired the Swiss Biostatistics & Data Management company Brunner & Hess.

Appletree CI Group is present in 9 European countries. The Group is privately �owned�.


Appletree CI Group is a specialized CSO (Contract Service Organization) in Winterthur, Switzerland offering services in clinical research and regulatory aeffairs.

At Appletree CI Group they believe in focusing on what they know best. Their core business is the development of ophthalmological and dermatological medicinesas well as medical device investigations. In addition, they are experts in pediatric studies and offers regulatory affairs services (DRA, RA) worldwide.

Appletree is the only contract research organization (CRO) in Europe with the combined expertise of medical devices and ophthalmology.


  • Clinical trials phases I-IV
  • Medical writing
  • pharmacovigilance
  • Data Management and biostatistics
  • Consulting
  • Clinical trial authorizations Europe
  • Marketing authorization applications
  • Life cycle management
  • variations management
  • Scientific advice

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